The main difference at the Domain level is that the organisms within each domain vary based on their chemistry and how they store their .

Based on their nucleotides in the cells ribosomal DNA, sensitivity to antibiotics and how they store fats.

Explanation:

Dormains are level of classification of animals and they are grouped into three based on differences in the nucleotides present in the ribosomal RNA, lipids present in their membrane structures and their sensitivity to antibiotics. The three major dormains are Archaea, bacteria and Eukarya.

Eukarya have membrane bound Nucleus.

not sure if this is what you'r looking for nnew= nold