What factors do you think might be making it difficult for farmers to treat this disease in their banana plants?

Panama disease. It's a fungus – known as fusarium wilt – that infects the root system of banana plants and, eventually, kills the plant. There is no cure for the disease, and when one plant is infected, an entire plantation can easily be brought down.

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Explanation:

it is a limiting nutrient limited by a single nutrient in the ecosystem, & the single goes very slow.