1. How can interactions among different stress factors operating at different levels of biological organization be accounted for in environmental risk assessment?

2. How do we improve risk assessment of environmental stressors to be more predictive across increasing environmental complexity and spatiotemporal scales?

3. How can we define, distinguish, and quantify the effects of multiple stressors on ecosystems?

4. How can we develop mechanistic modelling to extrapolate adverse effects across levels of biological organization?

5. How can we properly characterize the chemical use, emissions, fate, and exposure at different spatial and temporal scales?