Began as alternative medicine, but has now become so much like mainstream medicine that it is no longer considered a separate tradition.
A. Acupuncture
B. Osteopathic medicine
C. Herbal medicine
D. Crystal healing
E. Reflexology

if you know your abc's you should be able to get your answer or just use google

the correct answer is option d.

an appositive is a noun, noun phrase or noun clause which follows another noun or noun phrase in order to describe it or name it another way. they are usually used between commas, brackets or dashes.

the example sentence with the correct use of commas is the following:

her uncle, the man over there in the red shirt, owns the hardware store in town.

answer; (a) medicalized;