Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imatinib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?Choose one or more:
A.) oncogenes
B.) proteins with loss-of-function mutations
C.) proteins with gain-of-function mutations
D.) tumor suppressor genes

Ry was studying two populations of the same species of lizards. one population lived on an island and the other lived on the mainland. both populations were affected by a hurricane that hit the island and the mainland with equal force. a year later, henry was testing the gene frequency and saw a decrease in genetic variation in the island species, but not in the mainland species. which best describes a conclusion he might have reached? gene flow greatly affects small populations, but large populations can recover. genetic drift greatly affects small populations, but large populations can recover. gene flow greatly affects large populations, but small populations can recover. genetic drift greatly affects large populations, but small populations can recover.

Select the correct answer from each drop-down menu. in an experiment, dr. travis examined the effects of calcium intake on osteoporosis, a condition that causes an increased risk of bone fractures. the amount of calcium is variable. the risk of bone fractures .

African penguins, which inhabit the coasts of southern africa, were classified as an endangered species in 2010. two significant threats to their survival are ecosystem damage from oil spills and overfishing by humans. overfishing depletes the food supply of african penguins. the best method to reduce the threat of overfishing would be to . the risk of oil spills could be reduced by increasing the use of , which should oil consumption. if an oil spill does occur, could be used to remove the oil so the ecosystem may more quickly recover.