De novo purine synthesis occurs by the stepwise addition of atoms or groups of atoms to 5‑phosphoribosyl 1‑pyrophosphate (PRPP). The atoms of the purine rings are supplied by glutamate, glycine, glutamine, aspartate, and N 10 ‑formyltetrahydrofolate (THF). Inosine monophosphate (IMP), the product of the pathway, is a purine nucleotide that can be converted to either AMP or GMP. The structure of the base is labeled according to the numbering convention for purines. Identify the direct source of each atom in the purine ring of IMP.
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De novo purine synthesis occurs by the stepwise addition of atoms or groups of atoms to 5‑phosphorib...
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