In the early days of research on protein synthesis, some scientists observed that their most highly purified ribosome preparations, containing almost exclusively single ribosomes, were less active than preparations that were less highly purified. What is the likely explanation for this observation?

Polysomes are present in less highly purified preparation.

Explanation:

Polysome is a cluster of Ribosomes attached to a single strand of RNA. It is more active than the sample containing single ribosomes because polysome allow multiple ribosomes to translate mRNA at the same time, more than one ribosome can translate an mRNA at the same time making it more active.

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