The model describing allosteric regulation that requires subunits to change their state one-by-one is called the Group of answer choices Concerted model Syncopated model Cooperative model Equilibrium model Sequential model

Question:

The model describing allosteric regulation that requires subunits to change their state one-by-one is called

A) Concerted model

B) Syncopated model

C) Cooperative model

D) Equilibrium model

E) Sequential model

The correct answer is E) Sequential model.  

Explanation:

The sequential model (also known as simple sequential model) was proposed by Koshland Jr. in the year 1966.

The theory suggests that the aliosteric enzyme can exist in only two conformational changes individually.

The binding of the ligand causes conformational change in the other subunits of the multimeric protein. Although the subunits go through conformational changes independently (as opposed to in the MWC model), the switch of one subunit makes the other subunits more likely to change, by reducing the energy needed for subsequent subunits to undergo the same conformational change.

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