Which statement about Imipenem is accurate? a. active against methicillin-resistant staphylococci b. has a narrow spectrum of antibacterial action c. in renal dysfunction, dosage reduction is necessary to avoid seizures d. is used in fixed combination with sulbactam. e. is highly susceptible to beta-lactamases produced by Enterobacter species

c. in renal dysfunction, dosage reduction is necessary to avoid seizures

Explanation:

Imipenem is an antibiotic which is given in combination with cilastatin. It is used to treat pneumonia, joint infections, urinary tract infections, sepsis etc. It kills bacteria by interfering with its cell wall formation process. It is metabolized in kidney reducing its half life so cilastatin is given with it to halt its renal metabolism.

Imipenem belongs to carbapenem family of antibiotics. Carbapenem antibiotics can cause seizures specially in people with nervous system disorders or renal failure. Dose must be reduced in patients with renal (kidney) dysfunction otherwise patient's kidneys will be damaged more and since they are already in weak state, it can prove dangerous to the patient.

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