The central chemoreceptors that influence the control of breathing respond to changes in the . a. H₂ of mixed venous blood b. PCO₂ and H₂ of cerebral spinal fluid c. PO₂, pH, and PCO₂ of arterial blood d. PCO₂ and H₂ of mixed venous blood

The correct answer is option b. "PCO₂ and H₂ of cerebral spinal fluid".

Explanation:

The central respiratory chemoreceptors (CRCs) are cells involved in respiratory feedback and are located in the ventrolateral surface of medulla oblongata. CRCs respond to changes in the PCO₂ and H₂ of cerebral spinal fluid, contributing to the stimulation of breathing mainly by performing two processes: hypercapnia or metabolic acidosis.