Gaucher disease type 1 (GD1 ) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase.

Using the Hardy-Weinberg equilibrium equation, the frequency for the wild-type allele (referred to as p, see explanation below) comes out to be

Explanation:

An individual will have to be homozygous recessive for the mutation in the enzyme glucocerebrosidase to have the Gaucher disease type 1 (GD1). This percentage will be

= × 100 =

= =

We know that because the sum of both allele frequencies has to be 100%

So

Hence,

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step 1: nitrogen fixation- conversion of atmospheric no₂ into forms useful to plants by lightning, bacteria, and cyanobacteria.

step 2: nitrification-process of converting ammonia to nitrite or nitrate.

step 3: assimilation-plant roots absorb new form of nitrogen.

step 4: ammonification-conversion of organic nitrogen to ammonia by bacteria involved in decomposition.

step 5: denitrification-bacteria turns the decomposed matter back into n₂o, which is released into atmosphere; repeat cycle.