The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder?A) They would die as embryos. B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes. C) They would be lethargic and readily tire from exercise. D) They would carry out elevated levels of oxidative phosphorylation.

Explanation:

Phosphofructokinase (PFK) is a key enzyme in glycolysis that catalyzes the transfer of a phosphoryl group from ATP to fructose-6-phosphate and yield ADP and fructose-1,6-bisphosphate a key step in glycolysis. If Springer spaniels suffer from canine PFK deficiency then theprocess of  glycolysis will not occur properly, and the dogs would be lethargic and readily tire from exercise

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