The sickle cell mutation causes oxyhemoglobin molecules to due to hydrophobic interactions because a glutamate residue is replaced with a valine.

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Explanation:

Sickle cell is a disease caused by a mutation in the hemoglobin-Beta gene from chromosome 11. Sickle cell is one of the common blood diseases that inherited by autosomal recessive patterns.

The mutation will change the amino acid that composes the hemoglobin-Beta from glutamate into valine. The result of mutation makes the oxyhemoglobin to aggregate.

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