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Biology, 25.02.2020 18:59 mollybeale

A signaling pathway that stimulates cellular growth and division is positively regulated by a GTPase encoded by an autosomally located gene. During DNA replication in a cell within a large population of cells in culture, one of the two copies of this gene incurs a missense mutation that reduces the rate of hydrolysis of GTP to 1% of normal function.

Which of the following explanations best explains what effect this mutation might have on cells within this culture that are heterozygous for this mutation ?

Answers:

a. Because only one of the two copies of the GTPase encoding gene is affected, the cell will continue to grow and divide as normal.

b. Because the GTPase functions at a slower rate, signaling thought the pathway will occur with reduced efficiency and the cell's rate of growth and division will slow down.

c. Due to the reduced rate of hydrolysis of the GTP, signaling via the pathway will occur for a shorter period of time, so cells with the mutation will grow and divide more slowly.

d. Because the rate of hydrolysis is reduced, signaling will occur for a longer period of time and the cells will grow and divide more frequently.

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