Biology, 18.02.2020 19:53 skyler1muir

The figure to the right illustrates how a protein might bind to a drug substrate. There are five amino acids in the binding site, and they come into close contact with different functional groups on the drug molecule: 1- Histidine - hydroxyl 2- Aspartate - methyl 3- Glutamine - amine 4- Arginine - carboxylic acid5- Alanine - methyl A. List the number(s) of these pairs that can undergo favorable hydrogen bonding. B. List the number(s) of these pairs that can undergo favorable charge-charge interactions. C. List the number(s) of these pairs that can undergo hydrophobic interactions: D. Suppose you are asked to design a mutation that changes the identity of only one of these amino acids, and also strengthens the binding of the protein to the drug. Please propose a specific mutation and provide your reasoning why it would make the binding stronger. Amino acid #: Type of amino acid after mutation: Reasoning for stronger binding:

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The figure to the right illustrates how a protein might bind to a drug substrate. There are five ami...

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