Which complication may be increased because of the combined use of catechol ortho-methyltransferase (comt) inhibitors and monoamine oxidase inhibitors (maois)?

The correct answer is : increased risk of the cardiovascular disease.

Explanation:

Using the XCOMT and MAOIs together can lead to the high risk of cardiovascular disease due to the using these altogether cause lowering catecholamines.

There are several other condition can be arise due to not taking as prescribed such as taking COMT inhibitors empty stomach that result in GI upset however there is no direct impact on GI tract.

Thus, the correct answer is - increased risk of the cardiovascular disease.

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