Which of the following accounts for someone who has had a herpesvirus-mediated cold sore or genital sore getting flare-ups for the rest of his or her life?
a) re-infection by a closely related herpesvirus of a different strain
b) re-infection by the same herpesvirus strain
c) co-infection with an unrelated virus that causes the same symptoms
d) copies of the herpesvirus genome permanently maintained in host nuclei
e) copies of the herpesvirus genome permanently maintained in host cell cytoplasm

The correct answer is D) copies of the herpesvirus genome permanently maintained in host nuclei

Explanation:

Herpes virus causes sores that can be cold sores or genital sores which can be transferred sexually from an infected person to a normal person. The life cycle of any virus includes the integration of the viral genome into the host genome.  

So HSV can remain in a latent stage where no symptoms are seen but it can become reactive and cause flare-ups. The first flare-up is usually the worst than subsequent flare-ups.

So if anyone who had herpesvirus-mediated cold sore or genital sore getting flare-ups for lifetime then it can be suggested the viral genome copy permanently maintained in host nuclei which reactivates time to time.