To qualify, the condition must result from
lack of atp, and organism can't die as a result.

red blood cells Mitochondria are responsible for creating more than 90% of the energy that the body needs to sustain life and support growth. When they fail, less and less energy is generated inside the cell. There may then be cell injury or even cell death. If this process is repeated throughout the body, the complete systems begin to fail and the life of the person who suffers it is at serious risk. This disease primarily affects children, but outbreaks in adults are becoming more and more common.

Mitochondrial diseases appear to cause the greatest damage to the cells of the brain, heart, liver, skeletal muscle, kidney as well as the endocrine and respiratory systems.

Depending on which cells are affected, symptoms may include loss of motor control, muscle weakness and pain; gastrointestinal disorders and difficulties swallowing; poor growth, heart disease, liver disease, diabetes, respiratory complications, seizures, visual and hearing problems, lactic acidosis, developmental delays and susceptibility to infections.

WHEN TO SUSPECT THAT THERE IS A MITOCONDRIAL DYSFUNCTION

There is no unique feature to identify a mitochondrial disease. Patients have several problems that may arise from birth to adulthood. Think of mitochondria when:

A "common disease" has atypical characteristics that distinguish it from the rest.

There are three or more organs involved

Recurrent relapses occur, or when outbreaks of infection occur in a chronic disease.

Mitochondrial diseases or cytopathies should be considered as possible in differential diagnoses, when these unexplained characteristics appear, especially when they occur in combination with:

symptom

-Encephalopathy

-Convulsions

-Developmental Delay or Regression (including early dementia or late -episodes)

-Myoclonus

-Movement Disorders (dystonia, dyskinesias, chorea, etc.)

-Complicated Migraine

-Heart attacks

-Neuropathy

-Cardiac Duct Defects

 -Cardiomyopathies

-Hearing Impairments

-Short stature

-Extraocular Muscle Disorders

-cough

-acquired strabismus

-ophthalmoplegia

-Diabetes

-Renal Tubular Disease

-Sight loss

-retinitis pigmentosa

 -optic atrophy

-Lactic acidosis (may be mild)

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