Which observation would most seriously challenge the hypothesis that most noncoding dna is slightly deleterious?

- species with smaller population sizes have more noncoding dna.
- species with larger genomes lose dna more quickly through mutational processes than those with smaller genomes.
- there is an inverse relationship between the total amount of dna in the genome and the percentage of the dna that is noncoding.
- species with larger population sizes have more noncoding dna.
- species with larger genomes lose dna more slowly through mutational processes than those with larger genomes.