Whether during mitosis or meiosis, sister chromatids are held together by proteins referred to as cohesions. such molecules must have which of the following properties:
1. they must be removed before sister chromatids or homologous
chromosomes can separate.
2. they must be removed before meiosis can begin.
3. they must reattach to chromosomes during g1.
4. they must be intact for nuclear envelope re-formation.
5. they must persist throughout the cell cycle.

1. They must be removed before sister chromatids or homologous chromosomes can separate

Explanation:

During the S-phase of the cell cycle, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This replicated DNA (sister chromatids) remain physically connected with each other from S phase until metaphase. This physical connection is called Sister chromatids cohesion.

Sister chromatid cohesion depends on COHESIN, a tripartite protein complex that forms a ring structure to hold sister chromatids together during mitosis and meiosis. Cohesin regulates the separation of sister chromatids during cell division, either mitosis or meiosis. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic metaphase spindle, and is thus an essential prerequisite for chromosome segregation. Without the cohesion, sister chromatids would not be segregated symmetrically between the forming daughter cells, resulting in aneuploidy.

Cohesion is established during S-phase of DNA replication, and the cohesins hold the sister chromatid together after DNA replication until anaphase when the removal of cohesin leads to separation of sister chromatids (meiosis II and mitosis) and homologous chromosomes (meiosis I).

from almost the creation of the first true maps of the earth, people started seeing how continents would be able to fit together.   in particular, people noticed that south america fits almost exactly into africa.

you should be aware that while world maps were around early in the 1600’s and better defined by the end of the 1700’s, those maps were not ‘public’ but were treated as state secrets.   and so it was not till much later that the broader ‘science’ community had access to good quality and accurate world maps.

get the whole story here…

it is now known that most of the major continental masses can be fit together in a jigsaw process.   in fact we now know that the continents were indeed once all joined together as one land mass – the supercontinent of pangaea.

if you look at most world maps you will ponder how this is evidence, as the continents really don’t appear to ‘fit’ together very well.   what you need to understand is that the vast majority of maps are drawn using a map projection that has the north and south poles (which are points) are a line the width of the map at the top and bottom.   this means that the map distorts the true shape of the earth’s land and oceans as you love closer to the poles.     some other map projections distort less, but have the map shape looking like segments of an orange.   see here for a range of map projections.   check out the way greenland changes size in each!

what is more remarkable, is the next piece of evidence when added to the shape of continents.

location of mountains and fossils

what is remarkable, when you reassemble all the continents together, the ancient mountain ranges (many now eroded to their cores) and the location of rock types and fossils all match up.

this is math not biology xd