Which statement about the tumor suppressor gene p53 is false?

(a) it is required for apoptosis in response to dna damage.
(b) it blocks cell cycle progression in response to dna damage.
(c) it plays a role in up to 50% of human cancers.
(d) its loss causes retinoblastoma, a rare childhood cancer of the eye.

The correct answer is D its loss causes retinoblastoma a rare childhood cancer of the eye.

Explanation:

p53 is one of the most important tumor suppressor protein.It is named so because it has a molecular weight of 53 kd.p53 is encodes by TP53 gene.p53 play a significant role during apoptosis or programmed cell death.

 But the mutation in p53 does not cause retinoblastoma.Retinoblastoma is caused due to mutation in Retinoblastoma tumor suppressor protein.This disease is formed when both the allele of the retinoblatoma gene gets mutated.

from almost the creation of the first true maps of the earth, people started seeing how continents would be able to fit together.   in particular, people noticed that south america fits almost exactly into africa.

you should be aware that while world maps were around early in the 1600’s and better defined by the end of the 1700’s, those maps were not ‘public’ but were treated as state secrets.   and so it was not till much later that the broader ‘science’ community had access to good quality and accurate world maps.

get the whole story here…

it is now known that most of the major continental masses can be fit together in a jigsaw process.   in fact we now know that the continents were indeed once all joined together as one land mass – the supercontinent of pangaea.

if you look at most world maps you will ponder how this is evidence, as the continents really don’t appear to ‘fit’ together very well.   what you need to understand is that the vast majority of maps are drawn using a map projection that has the north and south poles (which are points) are a line the width of the map at the top and bottom.   this means that the map distorts the true shape of the earth’s land and oceans as you love closer to the poles.     some other map projections distort less, but have the map shape looking like segments of an orange.   see here for a range of map projections.   check out the way greenland changes size in each!

what is more remarkable, is the next piece of evidence when added to the shape of continents.

location of mountains and fossils

what is remarkable, when you reassemble all the continents together, the ancient mountain ranges (many now eroded to their cores) and the location of rock types and fossils all match up.

that is true   : ) hope this you