In mice, black color (b) is dominant to white (b). at a different locus, a dominant allele (a) produces a band of yellow just below the tip of each hair in mice with black fur. this gives a frosted appearance known as agouti. expression of the recessive allele (a) results in a solid coat color. if mice that are heterozygous at both loci are crossed, what is the expected phenotypic ratio of their offspring? a. huntington's diseaseb. tay-sachs diseasec. phenylketonuriad. cystic fibrosise. sickle-cell disease

Mr. j, age 42, is a construction worker in las vegas. he recently noticed that a mole on his face seemed to be getting larger and darker. at first he did not worry because he was in the sun a lot and assumed the change may have been caused by sunburn. after a month, not only was the mole larger and darker, but it appeared to be “bumpy.” his doctor diagnosed a malignant melanoma skin cancer following biopsy of the nevus. mr. j reports pain in his right shin that does not go away when he puts his feet up or sleeps. discussion questions 1. relate mr. j’s skin changes to the warning signs for malignant melanoma. (see malignant melanoma.) 2. discuss the normal progression of this malignancy. what is the significance of the bone pain that mr. j is experiencing? (see malignant melanoma.) 3. discuss the treatment available for this patient and the prognosis for recovery. (see malignant melanoma.)