Parkinson’s disease is a brain disorder that may be caused by mutations in several genes that code for the production of alpha-synuclein. individuals who have parkinson’s disease exhibit symptoms such as uncontrollable tremors, difficulty walking, and loss of coordination. how might geneticists determine where the mutations that cause parkinson’s disease are located?
a. pcr analysis
b. gene mapping
c. dna fingerprinting
d. str analysis

The right answer is gene mapping.

The act of mapping consists of determining the relative positions of the loci (genes or DNA sequences) on a chromosome. The binding maps are obtained from the recombination frequency between the loci. Physical maps are generally obtained by the use of in situ hybridization of cloned DNA fragments with metaphase chromosomes, or the use of somatic or hybrid irradiation hybrids.

Through gene mapping, mutations that cause Parkinson’s disease can be identified.

Further Explanation:

Parkinson’s disease is known to be a nervous system disorder that is progressive in nature and affects the movement of an individual. The symptoms begin slowly and generally start with a small very visible tremor in just one upper extremity. These tremors are common; however, the disorder also leads to hardness and restriction of movements. The familial cases of this can be the result of mutations in the following genes, LRRK2, PARK7, PINK1, PRKN, and SNCA.

Gene mapping illustrates the methods which are used to detect the locus of the gene as well as distances between the genes. The technique generally works by collecting molecular markers on their provided genome positions. These markers are in all types and can be viewed as one special kind of genetic marker while constructing the genome maps.

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Answer Details:

Grade: High school

Subject: Biology

Chapter: Genes and genetic diseases

Keywords:

Gene, gene mapping, mutations, markers, Parkinson’s disease, genome, distances, techniques, maps.