The michaelis-menten equation models the hyperbolic relationship between [s] and the initial reaction rate (v0) for an enzyme catalyzed, single substrate reaction: e s es e p. the model can be more readily understood when comparing three conditions: [s]km. match each statement with the condition that it describes. note: \"rate\" refers to initial velocity (v0) where steady state conditions are assumed; [etotal] refers to the total enzyme concentration, and [efree] refers to the concentration of free enzyme.

statements:

*es is much lower than etotal

*rate is directly proportional to s

*half of the active sites are filled with s

*almost all active sites will be filled

*this condition rarely occurs for most in vivo enzymes

*increasing etotal will increase km

4 conditions:

[s]<
[s]=km

[s]> > km

not true for any of these conditions