Signaling of gpcrs (g-protein coupled receptors) is terminated by which mechanism?
a. phosphorylation of receptors by camp (cyclic adenosine monophosphate) activated pka (protein kinase a), which blocks the interaction with g-protein
b. cleavage of the gpcrs by receptor-specific serine or threonine proteases
c. hydrolysis of gtp (guanosine triphosphate) to gdp (guonosine diphosphate) by g-protein α.
d. none of the above
e. all of the above

G protein coupled receptors signalling is terminated by phosphorylation of receptors by cyclic adenosine monophosphate activated protein kinase which blocks the interaction with G protein.

Explanation:

G protein coupled receptors (GPCR) signalling constitute a large protein family that detect molecules outside the cell and signal transduction internally and allow responses. They are majorly found in eukaryotes like yeast . The signalling of GPCR by G protein is terminated by phosphorylation of active receptor by GCPR kinases and protein kinase and also the binding of arrestin proteins.

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