What is the key to a large protein molecule dissolving in water?

Large protein molecule dissolve in water because the molecules contain hydrophilic groups on its surface.

Explanation:

Proteins are amphiphatic in nature containing both hydrophilic and hydrophobic groups.The hydrophilic groups are present in the surface area of protein molecule and the hydrophobic groups are buried inside the protein molecule.

    The hydrophilic groups that are present in the surface of protein molecule interacts with water by ionic interaction which ultimate help in dissolving a protein molecule in water.

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