The cortisol receptor once activated turns on genes. explain how this protein accomplishes this activity.

The cortisol is generally nothing but a hormone of a steroid category, which is produced by the adrenal glands as a reciprocation to any type of stress or low concentrations of glucose in the blood, also called glucocorticoid. It plays an essential role in all the vertebrates as it is accountable for conducting various activities associated with the metabolism, cardiovascular system, homeostasis, and immunity.  

The glucocorticoid receptors or the cortisol receptors are found to take place in the cytoplasm and carry the heat shock proteins alongside. When the hormone reaches these receptors and combines with them some modification in their conformation takes place, and two things occur, that is, the heat shock proteins are discharged, and a complex is produced by the hormone and the receptor, known as the G. R complex.  

This complex exhibits the tendency to move into the cytoplasm and performs the process of translation and transcription by combining it with the DNA. Here, it again can do two kinds of activities, that is, via transactivation it can result in the expression of the inflammatory proteins in the cytoplasm or via transrepression, it can repress the similar proteins.