Nonprotein, inorganic substances that enable enzymes to carry out chemical reactions are a. trace minerals. b. major minerals. c. ultratrace minerals. d. co-factors. e. hormones.

co-factors

Explanation:

Co-factors are the inorganic substances that are non-proteinaceous and assist the enzymes to efficiently carry out the various chemical reactions that take place in the body. These co-factors are usually derived from water-soluble vitamins through the process of phosphorylation. The enzyme in the absence of their cofactors is known as apo-enzyme however after it has bound to its cofactor it becomes fully functional and then is known as the holoenzyme. 

Libtards and libertarians

Iwould say overuse ( but not 100% sure ) in the u.s. we tend to overuse water by leaving it running, throwing it away, taking long showers, etc.