Gluconeogenesis is regulated by gluconeogenesis is regulated by concentration of its substrates allosteric modulation glucagon all of the above

All of the above

Explanation:

Control of gluconeogenesis is performed by glucagon, which stimulates this process, and by insulin, which acts in opposite way.

Glycogenesis is controlled by glycolysis and lives on, so that one pathway is virtually inactive while the other is in high activity. This reciprocal regulation between the two metabolic pathways contains several control points such as the phosphofructokinase and fructose 1,6-bisphosphatase enzymes, very important enzymes in the control of glycolysis and gluconeogenesis.  Fructose 1,6-bisphosphate functions as an intracellular signaling molecule indicating high levels of glucose in the body when present in large amounts in cells, which leads to activation of glycolysis and inactivation of gluconeogenesis through regulation of the above mentioned enzymes.