Sulfonamides interfere with sulfonamides interfere with anaerobic metabolism in protozoa protein synthesis in helminths folic acid synthesis in bacteria protein synthesis in fungi

Sulfonamides interfere with  folic acid synthesis in bacteria.

Explanation:

Sulfanilamide and other Sulfonamides are capable of inhibiting a variety of bacteria, interfering with a particular biochemical reaction (synthesis of the folic acid) which is essential for their survival. Sulfonamides are primarily used to treat urinary infections and for the treatment of otitis, bronchitis, sinusitis, and Pneumocystis pneumonia; It is used in combination with trimethoprim. Sulfonamides derivatives exert a wide range of antimicrobial activity against Gram-positive and Gram-negative bacteria.

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