Following on the question above, for decades it was also believe that microglia were the only immune cells in the cns, that they lived in there without any direct cellular communication to the immune system. thinking about the fact that functional immunity involves crosstalk among many cell types, this idea is flawed because it implies that the body has no ability to undergo response local to the cns
a) an innate immune response
b) an adaptive immune response

Define the apical impulse and describe its normal location, size, and duration. which abnormal conditions may affect the location of the apical impulse? explain the mechanism producing normal first and second heart sounds. describe the effect of respiration on the heart sounds. describe the characteristics of the first heart sound and its intensity at the apex of the heart and at the base. describe the characteristics of the second heart sound and its intensity at the apex of the heart and at the base.