Which one of the following enzymes of nucleotide metabolism is correctly paired with its pharmacologic inhibitor?

a. dihydrofolate reductase—methotrexate

b. inosine monophosphate dehydrogenase—hydroxyurea

c. ribonucleotide reductase—5-fluorouracil

d. thymidylate synthase—allopurinol

e. xanthine oxidase—probenecid

A. Dihydrofolate reductase—methotrexate

Explanation:

Dihydrofolate reductase is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid. Methotrexateis its inhibitor. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme.

Since folateis necassary for rapid dividing cells, such as cancer cells, methotrexate can be used as anticancer drug that inhibits DHFR.

thinking it would be physical characteristics

your spelling is a little off : ]