What are the adaptive immune responses induced following acute and chronic infection with hiv?

The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies that arise following a mucosal infection are usually derived from a single transmitted virus. Moreover, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently but they are too late to eliminate the infection. In this Review, we discuss recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine.

answer: the blood-brain barrier is a layer of specialized membranes and cell processes designed to keep undesirable substances from passing from the bloodstream into the precious tissues of the brain. while the blood-brain barrier does keep most bad things out of the central nervous system, it is not impermeable.

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