Novel combinations of genes can arise from novel combinations of genes can arise from reciprocal exchange of dna between homologs during prophase i reciprocal exchange of dna between sister chromatids during prophase the alignment of chromosomes at metaphase ii reciprocal exchange of dna between homologs during prophase ii

Correct A). Reciprocal exchange of dna between homologs during prophase i

Homologous recombination is genetic recombination in which the nucleotide sequences are exchanged among the two similar molecules of the DNA. It is used by the cells of the body to repair accurately harmful breaks that occur on the strand of DNA.

Homologous recombination occurs when there is an exchange of genetic material between the two strands of DNA. It usually takes place during the meiosis (Prophase I).

Hence, the correct answer would be option A.