Which of the following statements about enzymes is true? a. high temperatures can cause enzymes to denature which negatively affects the shape of the active site b. extremes in ph can cause enzymes to denature which negatively affects the shape pf the active site c. increasing the concentration of a substrate will increase the reaction rate of an enzyme reaction d. all of the above e. none of the above

All the enzymes are made up of proteins. Hence they have a definite structure which is mainly responsible for its activity. The high temperature can affect the structure of the enzyme which can destroy the active site of the enzyme which attaches to the substrate for their optimum activity. A high temperature can can denature the the proteins and negatively affect the shape of the active site of the enzyme. Hence the correct answer is option A.