Most new alleles probably arise from a. rearrangement of existing alleles into new combinations b. independent assortment of nonhomologous chromosomes c. large-scale changes in chromosome structure d. small-scale mutations in dna e. crossing over between homologous chromosomes

Answer;

- large-scale changes in chromosome structure

Explanation;

-Alterations to chromosome structure or changes in the number of copies of chromosomes in a cell.

-Allele frequencies in a population may change due to four fundamental forces of evolution: Natural Selection, Genetic Drift, Mutations and Gene Flow. Mutations are the ultimate source of new alleles in a gene pool. Mutation is important as the first step of evolution because it creates a new DNA sequence for a particular gene, creating a new allele.

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