Cancer cells are anaplastic in that they "form backward" to an earlier de-differentiated state. the cells have nuclei that vary in size and shape, termed

The cells have nuclei that vary in size and shape, termed pleomorphism.

Pleomorphism is usually defined in biology as the occurrence of multiple structural forms during the life cycle of an organism. In anaplasia, it represents multiple structural forms of nuclei. Pleomorphism is a characteristic feature found in malignant neoplasms, and dysplasia, but it can also be found in certain benign cell types.

affects the water bodies: excessive use of fertilizers causes eutrophication. the fertilizers which are used on plants affect the quality of land on which it is used, further causing erosion of soil. the fertilizers used on plants contain harmful chemical fumes which affect the environment.